ANTIBODIES A-Z

CD117

CD117 (c-Kit) is a transmembrane tyrosine kinase growth factor receptor involved in cell differentiation. It is expressed by melanocytes, mast cells and interstitial cells of Cajal, and is also expressed in gastrointestinal stromal tumours (GIST). Until recently, patients with GIST faced a limited choice of treatment regimes, which included radiotherapy and surgery with limited success. However, Glivec (Imatinib), which was originally developed for chronic myeloid leukaemia (CML), has proved effective in the targeted treatment of GISTs by directly inhibiting the action of CD117.